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Menopausal insomnia as a modifiable node of dementia risk: Mechanistic insights and intervention strategies 期刊论文

编号：

F9EA75B049531175CD7638D35700B902
作者：

Zhang, Wenjing#^[1,2]Zheng, Xuexin#^[3]Lian, Tenghong#^[4]Wang, Xiaomin^[5,6,7];Wang, Yuping^[8,9,10];Peng, Dantao(彭丹涛)^[11,12,13]Huang, Yuming^[1,2];Liu, Shunai*^[2,14]Zheng, Yunfeng*^[3,15]Zhang, Wei*^[4,16]
语种：

英文
期刊：

ALZHEIMERS & DEMENTIA ISSN：1552-5260 2026 年 22 卷 8 期 ; AUG 19
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关键词：

Alzheimer''s disease closed-loop neuromodulation dementia estrogen gamma rhythm inhibitory interneuron insomnia menopause NPTX2 PV rDMS sleep
摘要：

The menopausal transition is often accompanied by neuropsychiatric symptoms such as sleep disturbances, representing a modifiable window for Alzheimer''s disease and related dementia (ADRD) prevention. Current preventive strategies fail to address the heterogeneity of postmenopausal cognitive trajectories, where some women exhibit rapid cognitive decline while others maintain sustained resilience over decades. This divergence suggests distinct neuroendocrine mechanisms that remain poorly understood and untargeted by current interventions. Given estrogen''s fundamental role in brain function, compensatory enhancement of brain-local estrogen synthesis supports synaptic integrity and promotes resilience against neurodegeneration. Parvalbumin-positive (PV) interneurons enhance synaptic activity-dependent brain-derived estradiol (BDE2) synthesis in a sex-specific manner. Non-invasive gamma-rhythmic neuromodulation targeting PV interneurons via closed-loop protocols delivered during sleep can maximize therapeutic efficacy while minimizing off-target effects. A dual-cohort, parallel-group trial using neuronal pentraxin-2 (NPTX2) as a surrogate endpoint holds promise for assessing the efficacy of ADRD prevention and risk reduction in this high-risk population.
推荐引用方式
GB/T 7714：

Zhang Wenjing,Zheng Xuexin,Lian Tenghong, et al. Menopausal insomnia as a modifiable node of dementia risk: Mechanistic insights and intervention strategies [J].ALZHEIMERS & DEMENTIA,2026,22(8).
APA：

Zhang Wenjing,Zheng Xuexin,Lian Tenghong,Wang Xiaomin,&Zhang Wei.(2026).Menopausal insomnia as a modifiable node of dementia risk: Mechanistic insights and intervention strategies .ALZHEIMERS & DEMENTIA,22(8).
MLA：

Zhang Wenjing, et al. "Menopausal insomnia as a modifiable node of dementia risk: Mechanistic insights and intervention strategies" .ALZHEIMERS & DEMENTIA 22,8(2026).
入库时间：

2026/8/26 10:53:36
更新时间：

2026/8/26 10:53:36

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