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Association of placenta weight and morphology with term low birth weight: A case-control study 期刊论文

编号：

F3A76070C168A1740923CC96F71E9F9F
作者：

Liu, Jing(刘静)#^[1]Liu, Die(刘叠)^[1]Liang, Haixiao(梁海笑)^[1]Sun, Qi(孙琦)^[1]Chen, Yuanmei(陈源美)^[1]Ye, Fang(叶芳)^[1]Zhang, Qi(张琪)*^[1]
语种：

英文
期刊：

OPEN MEDICINE ISSN：2391-5463 2025 年 20 卷 1 期 ; SEP 26
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关键词：

placenta weight placenta morphology low birth weight term birth
摘要：

Background and aim Few studies identified the role of the placenta in birth weight. We aimed to explore the connection between placenta weight, morphology, and term low birth weight (TLBW). Methods This was a case-control study of neonates born at >= 37 weeks'' gestation enrolled in a general hospital from January 2018 to November 2022. Cases (<2,500 g) identified via birth certificates or medical records were matched with controls on the basis of date of birth, gestational age, sex, and maternal age. A nomogram predictive model was constructed based on logistic regression, using placenta parameters and perinatal information. Results A total of 290 neonates (115 with diagnosed TLBW and 175 controls) were determined. There were no significant differences between the two groups concerning gestational age (265.5 +/- 5.4 vs 266.3 +/- 5.3 days, P = 0.1397), gender, and maternal age at delivery (32.0 +/- 3.5 vs 32.1 +/- 3.1 years, P = 0.867). The placenta weight (479.0 +/- 80.1 vs 597.1 +/- 83.1 cm), length (16.3 +/- 2.1 vs 18.8 +/- 2.0 cm), width (14.3 +/- 2.1 vs 16.9 +/- 2.0 cm), and thickness (2.3 +/- 0.5 vs 2.4 +/- 0.4 cm) in the TLBW group were much lower than those in the control group (all P < 0.001). Univariate predictors of TLBW included smaller placental weight, length, width, thickness, volume, and surface area. When put into a multivariate model, placental weight (aOR for per 10 g increase: 0.89; 95% CI: 0.84-0.94) and width (aOR for per 1 cm increase: 0.69; 95% CI: 0.54-0.88) remained to be independent predictors even after controlling for relevant confounders. The odds of TLBW increased when placental weight was below the 50th percentile (aOR: 5.08, 95% CI: 2.59-9.95). Placental width below the 50th percentile was significantly associated with an increased risk of TLBW (aOR: 6.57, 95% CI: 2.73-15.82). Conclusions Placental weight and width were found to be associated with TLBW. Further studies focusing on placental function, histology, and pathophysiology are needed to better understand the underlying mechanisms influencing fetal growth and TLBW.
推荐引用方式
GB/T 7714：

Liu Jing,Liu Die,Liang Haixiao, et al. Association of placenta weight and morphology with term low birth weight: A case-control study [J].OPEN MEDICINE,2025,20(1).
APA：

Liu Jing,Liu Die,Liang Haixiao,Sun Qi,&Zhang Qi.(2025).Association of placenta weight and morphology with term low birth weight: A case-control study .OPEN MEDICINE,20(1).
MLA：

Liu Jing, et al. "Association of placenta weight and morphology with term low birth weight: A case-control study" .OPEN MEDICINE 20,1(2025).
入库时间：

2025/10/9 9:41:36
更新时间：

2025/10/19 21:29:43
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