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Developmental changes of the white matter functional connectome 期刊论文

编号：

B717C4BFF92B2E5AA89DF2128FA47D9E
作者：

Feng, Guozheng#^[1,2,3,4,5]Wang, Kexin^[1,2,3];Wang, Yichen^[1,2,3];Ma, Guolin(马国林)^[6]Cheng, Jian^[7];Calhoun, Vince D.^[4,5];Wang, Kai^[8];Ji, GongJun^[8,9,10,11];Shu, Ni^[1,2,3];
语种：

英文
期刊：

MOLECULAR PSYCHIATRY ISSN：1359-4184 2026 年 ; 2026 FEB 4
收录：
摘要：

Emerging studies have consistently shown that blood-oxygenation-level-dependent signals within white matter (WM) appear to be related to neural activity. This recognition of WM functional signal has provided a great opportunity to investigate how the brain''s WM functionally evolves in youth as well as its relationship to developmental disorders. Using multimodal imaging data from 407 participants aged 8 to 22 years, we constructed the WM functional connectome (WMFC) as well as the WM structural connectome (WMSC). Our findings reveal a global three-stage reorganization process in WMFC characterized by a decreasing-increasing-decreasing pattern. Regional changes are marked by hierarchical development between primary networks and higher-order networks. In conjunction with the WMSC, we measured WM SC-FC coupling, and found that coupling monotonically decreases with development. Treating these spatial patterns as phenotypes of WM function, we demonstrated significant regulation by neurotransmitter receptors and transcriptomic expression. Notably, WMFC significantly explained the heterogeneous regional vulnerability in neurodevelopmental disorders and outperformed the WMSC in predicting cognitive function. This study underscores the importance of investigating WM function in understanding the neural mechanisms of brain maturation and disorders.
推荐引用方式
GB/T 7714：

Feng Guozheng,Wang Kexin,Wang Yichen, et al. Developmental changes of the white matter functional connectome [J].MOLECULAR PSYCHIATRY,2026.
APA：

Feng Guozheng,Wang Kexin,Wang Yichen,Ma Guolin,&Shu Ni.(2026).Developmental changes of the white matter functional connectome .MOLECULAR PSYCHIATRY.
MLA：

Feng Guozheng, et al. "Developmental changes of the white matter functional connectome" .MOLECULAR PSYCHIATRY(2026).
入库时间：

2026/2/11 9:39:16
更新时间：

2026/2/11 9:39:16

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