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The interplay between antihypertensive medication and lifestyle with cardiovascular outcomes in patients with hypertension: the PURE-China study 期刊论文

编号：

AD9F3CAEBF5465B442C6B42AD083299A
作者：

Wang, Biyan#^[1]Liu, Zhiguang^[2];Bu, Tong^[1];Rangarajan, Sumathy^[3];Ma, Qiuyan^[1];Li, Xiaocong^[4];Qiu, Qi^[2];Lin, Yang^[2];Tse, Lap Ah^[5];Hu, Bo^[1];Yusuf, Salim^[3];Cai, Qiujing^[1];Li, Wei^[1];
语种：

英文
期刊：

EPMA JOURNAL ISSN：1878-5077 2026 年 ; 2026 FEB 26
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关键词：

Predictive Preventive Personalized Medicine (PPPM / 3PM) Cardiovascular disease Risk stratification Healthy lifestyle All-cause mortality Hypertension management Health risk assessment
摘要：

Objective Although antihypertensive medication is central to hypertension management, substantial residual risks persist. This study evaluated the associations of healthy lifestyle behaviors with all-cause mortality and cardiovascular disease (CVD) among individuals with hypertension, and assessed whether favorable lifestyles provided additional benefits beyond antihypertensive medication. From the perspective of predictive, preventive, and personalized medicine (PPPM/3PM), we assumed that comprehensive lifestyle assessment could refine risk stratification and help identify priority targets.
Methods This study included 16,314 participants with hypertension from the Prospective Urban Rural Epidemiology (PURE)-China study. A healthy lifestyle score (0-6, higher scores indicating healthier behaviors) was constructed based on six lifestyle behaviors. Antihypertensive medication use was defined as regular intake at least once per week. Cox frailty models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIS).
Results During a median follow-up of 11.9 years, 1,423 deaths and 2,418 CVD events occurred. Compared with the high score group (5-6), participants in the low score group (0-2) had higher risks of all-cause mortality (HR: 1.77, 95% CI 1.42-2.20) and CVD (HR: 1.56, 95% CI 1.28-1.89). Diet emerged as the strongest lifestyle predictor based on explained relative risk (R). Healthier lifestyles reduced all-cause mortality regardless of medication use, while an unfavorable lifestyle increased CVD risk among medication users.
Conclusions Among individuals with hypertension, healthier lifestyles were associated with lower risks of all-cause mortal-ity and CVD, independent of antihypertensive medication. Integrating lifestyle assessment into hypertension management may reduce risk in line with the PPPM/3PM framework.
推荐引用方式
GB/T 7714：

Wang Biyan,Liu Zhiguang,Bu Tong, et al. The interplay between antihypertensive medication and lifestyle with cardiovascular outcomes in patients with hypertension: the PURE-China study [J].EPMA JOURNAL,2026.
APA：

Wang Biyan,Liu Zhiguang,Bu Tong,Rangarajan Sumathy,&Li Wei.(2026).The interplay between antihypertensive medication and lifestyle with cardiovascular outcomes in patients with hypertension: the PURE-China study .EPMA JOURNAL.
MLA：

Wang Biyan, et al. "The interplay between antihypertensive medication and lifestyle with cardiovascular outcomes in patients with hypertension: the PURE-China study" .EPMA JOURNAL(2026).
入库时间：

2026/3/12 9:39:35
更新时间：

2026/3/12 9:39:35

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