首页 / 院系成果 / 成果详情页

Thalamic volume alterations mediate glymphatic function and cognitive dysfunction in Alzheimer's disease 期刊论文

编号：

9B3B69EECBA461C0C3E5501812FFF079
作者：

Chen, Leian#^[1]Zhou, Xiao^[2];Zhang, Bin^[3];Hou, Ying^[4,5];Sun, Yu^[5];Peng, Dantao(彭丹涛)*^[5]
语种：

英文
期刊：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS ISSN：2352-8737 2026 年 12 卷 3 期 ; AUG 6
收录：
关键词：

Alzheimer's disease cognitive function diffusion tensor image analysis along the perivascular space glymphatic system thalamus
摘要：

INTRODUCTION Glymphatic dysfunction is implicated in Alzheimer's disease (AD), but its mechanism remains unclear. This study investigated the associations of the analysis along the perivascular space (ALPS) index, brain reserve, and cognitive outcomes across the AD continuum. METHODS This study enrolled two cohorts from the local hospital (n = 95) and the Alzheimer's Disease Neuroimaging Initiative (ADNI; n = 178). We calculated the diffusion tensor image ALPS to assess the whole-brain glymphatic function and evaluated its associations with cognition and brain structure. RESULTS A higher ALPS index was positively associated with better executive, memory, and language abilities (p < 0.05). A lower ALPS index correlated with thalamic atrophy, involving the anterior, lateral, ventral, and midline thalamic nuclei. Thalamic atrophy mediated the link between glymphatic dysfunction and worse cognition via structural association of full or part mediation. CONCLUSIONS Glymphatic system deterioration correlates with cognitive decline, potentially mediated by thalamic atrophy. The thalamic nuclei may be critical in this pathway.
推荐引用方式
GB/T 7714：

Chen Leian,Zhou Xiao,Zhang Bin, et al. Thalamic volume alterations mediate glymphatic function and cognitive dysfunction in Alzheimer's disease [J].ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS,2026,12(3).
APA：

Chen Leian,Zhou Xiao,Zhang Bin,Hou Ying,&Peng Dantao.(2026).Thalamic volume alterations mediate glymphatic function and cognitive dysfunction in Alzheimer's disease .ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS,12(3).
MLA：

Chen Leian, et al. "Thalamic volume alterations mediate glymphatic function and cognitive dysfunction in Alzheimer's disease" .ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS 12,3(2026).
入库时间：

2026/8/27 21:36:05
更新时间：

2026/8/27 21:36:05

浏览次数：3  下载次数：0

分享到：

浏览次数：3

下载次数：0

打印次数：0