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Total tumor apparent diffusion coefficient histogram analysis of whole-body DWI-MRI for prognostic stratification in patients with R-ISS stage II multiple myeloma 期刊论文

编号：

9AEEB7A49B6E2AB1CF2A8725D78A803A
作者：

Zhou, Junde#^[1]Wang, Qin#^[1]Liu, Yanting#^[2]Zhang, Lu^[2];Li, Jiao*^[3]Li, Shuo^[1];Liu, Dong^[1];Zhu, Jinxia^[4];Grimm, Robert^[5];Stemmer, Alto^[5];Xia, Shuang^[6];Huang, Wenyang^[7,8];Xie, Sheng(谢晟)^[9]Zhang, Haibo(张海波)^[9]Li, Jian*^[2]Xue, Huadan*^[1]Jin, Zhengyu*^[1]
语种：

英文
期刊：

MAGNETIC RESONANCE IMAGING ISSN：0730-725X 2026 年 125 卷 ; JAN
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关键词：

Histogram parameters Multiple myeloma Apparent diffusion coefficient Whole-body diffusion-weighted imaging
摘要：

Purpose: This study aimed to explore the utility of total tumor apparent diffusion coefficient (ttADC) histogram analysis based on whole-body diffusion-weighted magnetic resonance imaging (DWI-MRI) for prognostic stratification in patients with Revised International Staging System stage II (R-ISS II) multiple myeloma (MM). Methods: Patients with R-ISS II MM who underwent baseline whole-body MRI prior to treatment were retrospectively enrolled. The ttADC histogram parameters of the whole-body DWI-MRI were obtained using MR Total Tumor Load software (Siemens Healthcare, Erlangen, Germany). The overall survival (OS) and the progressionfree survival (PFS) of the cohort was recorded. Cox regression analyses were used to evaluate the clinical features and ttADC histogram parameters for their association with OS and PFS. Results: A total of 61 R-ISS II MM patients were retrospectively included. During a mean follow-up period of 80 months, 27 patients died, 4 patients lost follow-up for OS, and 4 patients lost follow-up for PFS. Multivariate analysis revealed that increased median ttADC (>= 0.620 x 10-3 mm2/s) [hazard ratio (HR) = 2.291, P = 0.046, 95 % confidence interval (CI): 1.014-5.175] was independently associated with OS in R-ISS II MM patients. No significant association was observed between the ttADC histogram parameters and PFS. Conclusion: The median ttADC of whole-body DWI-MRI is an independent predictor of OS in R-ISS II MM patients, suggesting its potential role in further prognostic stratification in this patients'' subgroup.
推荐引用方式
GB/T 7714：

Zhou Junde,Wang Qin,Liu Yanting, et al. Total tumor apparent diffusion coefficient histogram analysis of whole-body DWI-MRI for prognostic stratification in patients with R-ISS stage II multiple myeloma [J].MAGNETIC RESONANCE IMAGING,2026,125.
APA：

Zhou Junde,Wang Qin,Liu Yanting,Zhang Lu,&Jin Zhengyu.(2026).Total tumor apparent diffusion coefficient histogram analysis of whole-body DWI-MRI for prognostic stratification in patients with R-ISS stage II multiple myeloma .MAGNETIC RESONANCE IMAGING,125.
MLA：

Zhou Junde, et al. "Total tumor apparent diffusion coefficient histogram analysis of whole-body DWI-MRI for prognostic stratification in patients with R-ISS stage II multiple myeloma" .MAGNETIC RESONANCE IMAGING 125(2026).
入库时间：

2025/11/12 8:51:03
更新时间：

2025/11/30 21:28:57
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