Background: Transdermal drug delivery technologies (TDDTs) enhance drug absorption and therapeutic outcomes in dermatology, yet standardized, evidence-based recommendations for their clinical application remain lacking. Objective: To provide expert consensus recommendations on the clinical application of TDDTs, with a focus on fractional lasers and microneedles. Methods: A multidisciplinary panel of 25 experts systematically reviewed current literature and clinical practices. The consensus was developed using the Grading of Recommendations Assessment, Development and Evaluation framework to assess evidence quality and recommendation strength and the modified Delphi method to achieve expert agreement. Results: Evidence-based recommendations were formulated for the use of TDDTs in a variety of dermatological conditions, including cutaneous malignancies and precancerous lesions, viral warts, inflammatory and autoimmune skin diseases, and cosmetic indications. Conclusion: Fractional lasers and microneedles are valuable transdermal delivery tools for dermatological therapy. This expert consensus provides practical, evidence-based guidance to support their safe and effective clinical use. (JAAD Int 2026;27:169-77.)
[1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Dermatol, 1277 Jiefang Ave, Wuhan 430022, Hubei, Peoples R China.
[2]Tongji Univ, Shanghai Skin Dis Hosp, Inst Photomed, Sch Med, Shanghai, Peoples R China.
[3]Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai, Peoples R China.
[4]Eberhard Karls Univ Tubingen, Dept Dermatol, Tubingen, Germany.
[5]Womens Coll Hosp, Womens Coll Res Inst, Toronto, ON, Canada.
[6]Univ Toronto, Dept Med, Div Dermatol, Toronto, ON, Canada.
[7]Nirvan Skin Clin, Vadodara, India.
[8]Univ Lubeck, Inst & Comprehens Ctr Inflammat Med, Lubeck, Germany.
[9]Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian, Peoples R China.
[10]Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha, Peoples R China.
[11]Jilin Univ, Dept Dermatol, China Japan Union Hosp, Changchun, Peoples R China.
[12]Wuhan Univ, TaiKang Ctr Life & Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China.
[13]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Shanghai Inst Immunol,Sch Med,Translat Med Ctr, Key Lab Cell Differentiat & Apoptosis,Chinese Mini, Shanghai, Peoples R China.
[14]Peking Univ, Peoples Hosp, Dept Dermatol, Beijing, Peoples R China.
[15]Hainan Prov Hosp Skin Dis, Dept Dermatol, Haikou, Peoples R China.
[16]Wuhan Univ, Dept Dermatol, Zhongnan Hosp, Wuhan, Peoples R China.
[17]Tongji Univ, Sch Med, Shanghai Skin Dis Hosp, Dept Dermatol, Shanghai, Peoples R China.
[18]Tongji Univ, Sch Med, Inst Psoriasis, Shanghai, Peoples R China.
[19]Cosmet Laser Dermatol, San Diego, CA USA.
[20]Chongqing Med Univ, Affiliated Hosp 3, Dept Dermatol, Chongqing, Peoples R China.
[21]Int Mongolian Hosp Inner Mongolia, Dept Dermatol, Hohhot, Peoples R China.
[22]Zhejiang Univ, Dept Dermatol, Sch Med, Affiliated Hosp 2, Hangzhou, Peoples R China.
[23]Xiamen Chang Gung Hosp, Dept Dermatol, Xiamen, Peoples R China.
[24]Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
[25]Shihezi Univ, Affiliated Hosp 1, Sch Med, Dept Stomatol, Shihezi, Peoples R China.
[26]Cent South Univ, Xiangya Hosp 2, Dept Dermatol, Changsha, Peoples R China.
[27]Ningxia Med Univ, Dept Dermatol, Gen Hosp, Yinchuan, Peoples R China.
[28]Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China.
[29]Hubei Key Lab Bioinorgan Chem & Mat Med, Wuhan, Peoples R China.
[30]Hubei Engn Res Ctr Biomat & Med Protect Mat, Wuhan, Peoples R China.
[31]Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan, Peoples R China.
[32]China Japan Friendship Hosp, Dept Dermatol, Beijing, Peoples R China.
[33]Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Dermatol, Beijing, Peoples R China.
[34]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Wuhan, Peoples R China.
[35]Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Nanjing, Peoples R China.
[36]Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Dermatol, Wuhan, Peoples R China.
[37]China Med Univ, Hosp 1, Dept Dermatol, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China.
(8.0+极速模式)