首页 / 院系成果 / 成果详情页

Lower Respiratory Microbiome Dysbiosis Is Associated With Poor Prognosis in Acute Severe Lower Respiratory Tract Infection 期刊论文

编号：

61188FF0687FD135F4ECCB2BF91DBADF
作者：

Zhan, Minghua#^[1,2]Chen, Hongbin^[1];Li, Ziyao^[3];Liu, Si^[1];Lu, Binghuai^[3,4];Wang, Zhang^[5];Wang, Hui^[1];
语种：

英文
期刊：

MEDCOMM ISSN：2688-2663 2026 年 7 卷 8 期 ; AUG 9
收录：
关键词：

acute severe lower respiratory tract infections immune responses lower respiratory tract microbiome mNGS
摘要：

Acute severe lower respiratory tract infections (asLRTIs) pose a significant clinical challenge, especially in critically ill patients, but the role of the lower respiratory tract microbiome (LRTM) remains unclear. This study aimed to characterize LRTM composition and host immune factors to identify prognostic features of clinical outcomes. The study included 53 asLRTI patients and 35 controls. Metagenomics, metabolomics, proteomics, and RNA sequencing were conducted, while analysis of similarities (ANOSIM) and Cox regression were performed for statistics. Clinical data, including pneumonia severity scores, were collected on BALF sampling, with a 100-day follow-up. LRTM samples were grouped into five clusters (C1-C5). Cluster C5 resembled controls, while others showed significantly lower diversity. LRTM composition correlated with prognosis, with higher pathogenic bacteria abundance linked to poorer outcomes. Cluster C3 was associated with poor prognosis and reduced survival. Metabolite analysis revealed elevated alpha-ketoisocaproic acid in asLRTIs and higher 10-nitrolinoleate in poor-prognosis patients. Immune responses varied across clusters, with distinct gene and cytokine expression patterns. Cluster C1, associated with Acinetobacter baumannii, exhibited heightened IL17 pathway activation. LRTM composition in asLRTIs is linked to clinical outcomes, with no single gradient of difference but distinct community states characterized by varying pathogens, metabolites, and immune responses.
推荐引用方式
GB/T 7714：

Zhan Minghua,Chen Hongbin,Li Ziyao, et al. Lower Respiratory Microbiome Dysbiosis Is Associated With Poor Prognosis in Acute Severe Lower Respiratory Tract Infection [J].MEDCOMM,2026,7(8).
APA：

Zhan Minghua,Chen Hongbin,Li Ziyao,Liu Si,&Wang Hui.(2026).Lower Respiratory Microbiome Dysbiosis Is Associated With Poor Prognosis in Acute Severe Lower Respiratory Tract Infection .MEDCOMM,7(8).
MLA：

Zhan Minghua, et al. "Lower Respiratory Microbiome Dysbiosis Is Associated With Poor Prognosis in Acute Severe Lower Respiratory Tract Infection" .MEDCOMM 7,8(2026).
入库时间：

2026/8/27 21:36:10
更新时间：

2026/8/27 21:36:10

浏览次数：3  下载次数：0

分享到：

浏览次数：3

下载次数：0

打印次数：0