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EBUS-guided transbronchial mediastinal cryobiopsy for diagnosing non-metastatic lymphadenopathy: A randomized controlled trial 期刊论文

编号：

4809B8C9DF511081C23C91DAF3B32061
作者：

Deng, Mingming#^[1]Zheng, Ziwen^[1,2];Zhang, Xiaofei^[3,4];Xia, Yang^[5];Tang, Fei^[6,7];Yang, Zhen^[8];Zhong, Changhao^[9];Tong, Run^[1];Zhou, Guowu^[1];Li, Xuelian^[10];Zhao, Ling(赵玲)^[11]Dai, Huaping^[1];Hou, Gang^[1];
语种：

英文
期刊：

MED ISSN：2666-6359 2026 年 7 卷 2 期 ; FEB 13
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摘要：

Background: Non-metastatic lymphadenopathy is challenging to diagnose. The comparative diagnostic performance of endobronchial ultrasound (EBUS)-guided transbronchial mediastinal cryobiopsy (TBMC) vs. EBUS-transbronchial needle aspiration (TBNA) remains debated. Methods: This multicenter randomized trial was conducted in three hospitals. Patients with at least one mediastinal and/or hilar lesion of >= 1 cm in the short axis who required diagnostic bronchoscopy were included. The patients were randomized in a 1:1 ratio to receive either EBUS-TBNA followed by EBUS-TBMC (EBUS-TBNA-first group) or EBUS-TBMC followed by EBUS-TBNA (EBUS-TBMC-first group). The primary outcome was the diagnostic yields of EBUS-TBMC and EBUS-TBNA. Findings: The overall diagnostic yield of EBUS-TBMC for non-metastatic lymphadenopathy was significantly higher than that of EBUS-TBNA for specific benign etiologies and lymphomas (97.1% vs. 79.9%, p < 0.001). In the subgroup analysis, EBUS-TBMC showed a higher sensitivity for sarcoidosis than EBUS-TBNA (98.0% vs. 82.7%, p < 0.001). All patients experienced grade 1 airway bleeding. Conclusions: EBUS-TBMC demonstrated a higher diagnostic yield than EBUS-TBNA for non-metastatic lymphadenopathy in a cohort almost exclusively composed of sarcoidosis cases, with a good safety profile. EBUS-TBMC is a potential first-line diagnostic tool for non-metastatic lymphadenopathy.
推荐引用方式
GB/T 7714：

Deng Mingming,Zheng Ziwen,Zhang Xiaofei, et al. EBUS-guided transbronchial mediastinal cryobiopsy for diagnosing non-metastatic lymphadenopathy: A randomized controlled trial [J].MED,2026,7(2).
APA：

Deng Mingming,Zheng Ziwen,Zhang Xiaofei,Xia Yang,&Hou Gang.(2026).EBUS-guided transbronchial mediastinal cryobiopsy for diagnosing non-metastatic lymphadenopathy: A randomized controlled trial .MED,7(2).
MLA：

Deng Mingming, et al. "EBUS-guided transbronchial mediastinal cryobiopsy for diagnosing non-metastatic lymphadenopathy: A randomized controlled trial" .MED 7,2(2026).
入库时间：

2026/3/15 21:05:15
更新时间：

2026/3/15 21:05:15

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