首页 / 院系成果 / 成果详情页

A Pseudo-Mytilus Edulis Foot Protein-Based Hydrogel Adhesive with Osteo-Vascular-Immune Coupling Effects for Osteoporotic Bone-Implant Integration 期刊论文

编号：

47A90C244FEBDB860CC973937DBF5FD1
作者：

Wang, Wentao#^[1,2]Li, Zhenyu#^[1]Zhang, Siming#^[1]Ma, Yue*^[3]Yu, Lei^[4];Zhang, Qidong(张启栋)^[5]Pan, Guoqing^[3];Geng, Dechun*^[6]Zhu, Chen*^[1]Bai, Jiaxiang*^[1]
语种：

英文
期刊：

ADVANCED MATERIALS ISSN：0935-9648 2026 年 38 卷 6 期 ; JAN 1
收录：
关键词：

dual interface adhesive immunomodulation macrophage polarization osteoporosis pH-responsive
摘要：

The reduced initial stability of orthopedic implants in osteoporotic bone matrices, coupled with excessive M1 macrophage polarization at bone-implant interfaces, disrupt bone-immune homeostasis and vascularization, ultimately leading to implant loosening or failure. Inspired by the marine mussel Mytilus edulis foot protein (Mefp), a pH-responsive multifunctional bone glue (YDC-Gel-Zn) with broad-spectrum adhesion capabilities is developed for osteoporotic bone-implant integration. This pseudo-Mefp bioglue enables dual-interface adhesion via catechol-rich sequences that mediate stable metal-phenolic coordination with metallic implants and hydrogen-bonded/Michael addition-driven interactions with the bone matrix, thereby improving initial implant fixation. Under osteoporotic inflammatory microenvironments, sequential dissociation of borate ester bonds and metal-phenolic coordination facilitates the controlled release of Zn2(+) and proangiogenic/osteogenic peptides (YDC). The released Zn2(+) remodels glutathione metabolism through glutathione S-transferase (GST)-mediated regulation of glutathione (GSH) levels, inhibits JAK1/STAT1/NLRP3 inflammasome activation, and suppresses the release of proinflammatory cytokines from senescent M1 macrophages, recalibrating the osteo-vascular-immune microenvironment. Due to its positive effects on bone regeneration and angiogenesis, the bioinspired bone bioglue demonstrated a 194% increase in fixation strength in osteoporotic rat models, achieving 93% healthy bone-implant stability. Overall, this study provides a clinically translatable strategy for stable implantation under osteoporotic conditions through synergistic mechanical adaptation, bioactivity regulation, and smart environmental responsiveness.
推荐引用方式
GB/T 7714：

Wang Wentao,Li Zhenyu,Zhang Siming, et al. A Pseudo-Mytilus Edulis Foot Protein-Based Hydrogel Adhesive with Osteo-Vascular-Immune Coupling Effects for Osteoporotic Bone-Implant Integration [J].ADVANCED MATERIALS,2026,38(6).
APA：

Wang Wentao,Li Zhenyu,Zhang Siming,Ma Yue,&Bai Jiaxiang.(2026).A Pseudo-Mytilus Edulis Foot Protein-Based Hydrogel Adhesive with Osteo-Vascular-Immune Coupling Effects for Osteoporotic Bone-Implant Integration .ADVANCED MATERIALS,38(6).
MLA：

Wang Wentao, et al. "A Pseudo-Mytilus Edulis Foot Protein-Based Hydrogel Adhesive with Osteo-Vascular-Immune Coupling Effects for Osteoporotic Bone-Implant Integration" .ADVANCED MATERIALS 38,6(2026).
入库时间：

2025/11/12 8:51:04
更新时间：

2025/11/30 21:29:37
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：17  下载次数：0

分享到：

浏览次数：17

下载次数：0

打印次数：0