首页 / 院系成果 / 成果详情页

π-HuB: the proteomic navigator of the human body  期刊论文  

  • 编号：
    444C6DFC041D07B18701C7F556F3F834
  • 作者：
    He, Fuchu#*[1,2]Aebersold, Ruedi*[3]Baker, Mark S.[4];Bian, Xiuwu[5,6,7];Bo, Xiaochen[8];Chan, Daniel W.[9,10];Chang, Cheng[1];Chen, Luonan[11];Chen, Xiangmei[12];Chen, YuJu[13];Cheng, Heping[14];Collins, Ben C.[15];Corrales, Fernando[16];Cox, Juergen[17];Weinan, E.[18,19];Van Eyk, Jennifer E.[20];Fan, Jia[21];Faridi, Pouya[22,23];Figeys, Daniel[24,25];Gao, George Fu[26];Gao, Wen[27,28];Gao, ZuHua[29];Goda, Keisuke[30,31,32];Goh, Wilson Wen Bin[33];Gu, Dongfeng[34];Guo, Changjiang[35];Guo, Tiannan[36,37,38];He, Yuezhong[2];Heck, Albert J. R.[39,40,41];Hermjakob, Henning[42];Hunter, Tony[43];Iyer, Narayanan Gopalakrishna[44];Jiang, Ying[1];Jimenez, Connie R.[45];Joshi, Lokesh[46];Kelleher, Neil L.[47];Li, Ming[48,49];Li, Yang[1];Lin, Qingsong[50];Liu, Cui Hua[51];Liu, Fan[52];Liu, GuangHui[53];Liu, Yansheng[54];Liu, Zhihua[55];Low, Teck Yew[56];Lu, Ben[57,58];Mann, Matthias[59];Meng, Anming[60];Moritz, Robert L.[61];Nice, Edouard[62];Ning, Guang[63,64,65];Omenn, Gilbert S.[66];Overall, Christopher M.[67,68];Palmisano, Giuseppe[69];Peng, Yaojin[70,71,72];Pineau, Charles[73];Poon, Terence Chuen Wai[74];Purcell, Anthony W.[75,76];Qiao, Jie[77];Reddel, Roger R.[78];Robinson, Phillip J.[78];Roncada, Paola[79];Sander, Chris[80,81];Sha, Jiahao[82];Song, Erwei[83,84];Srivastava, Sanjeeva[85];Sun, Aihua[1];Sze, Siu Kwan[86];Tang, Chao[87];Tang, Liujun[1];Tian, Ruijun[2,88];Vizcaino, Juan Antonio[42];Wang, Chanjuan;Wang, Chen(王辰)[89,90]Wang, Xiaowen[1];Wang, Xinxing[35];Wang, Yan[1];Weiss, Tobias[91,92];Wilhelm, Mathias[93];Winkler, Robert[94];Wollscheid, Bernd[95];Wong, Limsoon[96,97];Xie, Linhai[1];Xie, Wei[60];Xu, Tao[98,99];Xu, Tianhao;Yan, Liying[77];Yang, Jing[98];Yang, Xiao[1];Yates, John[100];Yun, Tao[101];Zhai, Qiwei[102];Zhang, Bing[103,104];Zhang, Hui[105];Zhang, Lihua[106];Zhang, Lingqiang[1];Zhang, Pingwen[107,108];Zhang, Yukui[106];Zheng, Yu Zi[2,29];Zhong, Qing[78];Zhu, Yunping[1];Tan, Chris Soon Heng[88];Gao, Mingxia[109];Gao, Qiang[21];Gao, Yushun[89];Guo, Xuejiang[82];He, Jie[89];He, Jun[110];He, QingYu[111];Hou, Jinlin[112];Huang, Canhua[113,114];Jia, Chenxi[1];Kuster, Bernhard[93];Li, Chaoying[1];Li, Dong[1];Li, Yanchang[1];Liu, Siqi[116];Liu, Xiaonan[117];Liu, Ya[117];Liu, Zhongyang[1];Lu, Haojie[109];Nie, Yongzhan[117];Okada, Mariko[118];Qian, Guojun[119];Qin, Hongqiang[106];Rao, Yu[120];Rao, Zihe[121];Ren, Xianwen[122];Ren, Yan[116,123];Shen, Feng[119];Shen, Lin[115];Su, Shicheng[83,84];Tan, Minjia[124];Tang, Ben Zhong[125];Tao, ShengCe[126];Wang, Jian[1];Wang, Tong[111];Wei, Liming[109];Wong, Catherine C. L.[89];Xie, Xiaoliang Sunney[122,127];Xu, Li[128];Xu, Ping[1];Yang, Huanming[116];Yang, Jianjun[117];Ye, Mingliang[106];Ying, Wantao[1];Yu, Xiaobo[1];Yuan, Yaxiang[129];Zeng, Qingcun[130];Zhan, Qimin[115,131];Zhang, Xiaofei[110];Zhang, Xu[132];Zhang, Ying[109];Zhong, NanShan[98,133];Zhou, Feng[109];Zhu, Yi[36,37,38];Zhang, Zemin[122,127];
  • 语种：
    英文
  • 期刊：
    NATURE ISSN：0028-0836 2024 年 636 卷 8042 期 (322 - 331) ; DEC 12
  • 收录：
     
  • 摘要：

    The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual''s body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies. Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body at unprecedented resolution and scale. Here we introduce a big-science endeavour called pi-HuB (proteomic navigator of the human body). The aim of the pi-HuB project is to (1) generate and harness multimodality proteomic datasets to enhance our understanding of human biology; (2) facilitate disease risk assessment and diagnosis; (3) uncover new drug targets; (4) optimize appropriate therapeutic strategies; and (5) enable intelligent healthcare, thereby ushering in a new era of proteomics-driven phronesis medicine. This ambitious mission will be implemented by an international collaborative force of multidisciplinary research teams worldwide across academic, industrial and government sectors.

  • 推荐引用方式
    GB/T 7714：
    He Fuchu,Aebersold Ruedi,Baker Mark S., et al. π-HuB: the proteomic navigator of the human body [J].NATURE,2024,636(8042):322-331.
  • APA：
    He Fuchu,Aebersold Ruedi,Baker Mark S.,Bian Xiuwu,&Zhang Zemin.(2024).π-HuB: the proteomic navigator of the human body .NATURE,636(8042):322-331.
  • MLA：
    He Fuchu, et al. "π-HuB: the proteomic navigator of the human body" .NATURE 636,8042(2024):322-331.
  • 入库时间：
    1/15/2025 9:31:34 AM
  • 更新时间：
    1/15/2025 9:31:34 AM
  • 条目包含文件：
    文件类型：PDF,文件大小：
    正在加载全文
浏览次数：4 下载次数：0
分享到：
浏览次数：4
下载次数：0
打印次数：0

网站总浏览量： 次   

Copyright © 中日友好医院

技术支持：北京同舟云网络信息技术有限公司

浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部