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Short-term performance of bleeding risk scores in anticoagulated older patients with acute pulmonary embolism 期刊论文

编号：

43115D191CCE5E6AC08D9C4DA5412884
作者：

Tao, Yuzhi#^[1,2,3]Meng, Xianglong^[1,2];Tian, Han^[3];Li, Xincheng^[4];Liang, Rui^[5];Chen, Yinong^[6];Chen, Hong^[7];Dong, Chunling^[8];Shi, Yiwei^[9];Xu, Xiaomao^[10];Wang, Maoyun^[11];Zhu, Ling^[12];Ji, Yingqun^[13];Shi, Juhong^[14];Cheng, Zhe^[16];Li, Yanxia^[17];Deng, Chaosheng^[18];Luo, Qin^[19];Lu, Pinyao^[20];Zhang, Yu^[3];Xi, Linfeng^[3];Wan, Jun^[6];Miao, Ran^[3];Yang, Peiran^[21];Xiong, Changming^[22];Peng, Liping^[23];Wang, Shengfeng^[1,2];Zhai, Zhenguo^[5];Wang, Chen^[5];
语种：

英文
期刊：

THROMBOSIS RESEARCH ISSN：0049-3848 2026 年 263 卷 ; JUL
收录：
关键词：

Pulmonary embolism Anticoagulation Bleeding Older adults Score
摘要：

Background: Older patients with pulmonary embolism (PE) are at increased risk of bleeding, which is associated with adverse outcomes, making early risk assessment particularly important. This study evaluated the short-term performance of commonly used bleeding risk scores in patients aged >= 65 years. Methods: An analysis was conducted in a multicenter, prospective study of patients aged >= 65 years with PE receiving anticoagulation (NCT02943343, 2016). The performance of the PE-SARD, Kuijer, RIETE, BACS, and ATRIA scores was evaluated using the time-dependent area under the curve (AUC) analysis. Calibration was assessed with calibration plots. Sensitivity, specificity, and positive predictive values were calculated. The primary outcomes were major bleeding (MB) at 7 and 14 days. Results: Among 3661 anticoagulated patients aged >= 65 years with acute PE, MB occurred in 18 (0.5%) and 36 (1.0%) patients at 7 and 14 days, respectively, and clinically relevant non-major bleeding (CRNMB) in 69 (1.9%) and 105 (2.9%) patients. Patients with bleeding events had higher mortality than those without bleeding. Discrimination for short-term MB was low to moderate across scores, with RIETE (AUC 0.76, 95% CI 0.65-0.87) and PE-SARD (AUC 0.74, 95% CI 0.63-0.85) showing the most consistent performance at 7 days. Overall discrimination declined at 14 days. All scores demonstrated limited ability to predict CRNMB, and no model showed a consistent net clinical benefit. Conclusions: In older patients with PE, bleeding risk scores showed low-to-moderate discrimination for short-term bleeding, with moderate early performance observed only in selected scores. None of the scores reliably identified CRNMB, highlighting the limitations of baseline risk assessment in acute care settings.
推荐引用方式
GB/T 7714：

Tao Yuzhi,Meng Xianglong,Tian Han, et al. Short-term performance of bleeding risk scores in anticoagulated older patients with acute pulmonary embolism [J].THROMBOSIS RESEARCH,2026,263.
APA：

Tao Yuzhi,Meng Xianglong,Tian Han,Li Xincheng,&Wang Chen.(2026).Short-term performance of bleeding risk scores in anticoagulated older patients with acute pulmonary embolism .THROMBOSIS RESEARCH,263.
MLA：

Tao Yuzhi, et al. "Short-term performance of bleeding risk scores in anticoagulated older patients with acute pulmonary embolism" .THROMBOSIS RESEARCH 263(2026).
入库时间：

2026/7/8 9:35:33
更新时间：

2026/7/8 9:35:33

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