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Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis 期刊论文

编号：

40EEEFF71A1C4428EC932F00F0BB4BD4
作者：

Zhang, Lanlan#*^[1]Gui, Xuezhen#^[1]Hou, Ruijie#^[1]Jia, Liping#^[1]Xia, Shu#^[2]Zhang, Xin^[3];Fu, Yingyun^[4,5,6];Meng, QianFang^[7];Luo, Qun^[2];Shi, Xing^[4,5];Guo, Bingxin^[4,5,6];Liang, Ruifang^[4,5,6];Yue, Ludan^[7];Chen, Xue^[4,5,6];Xu, Haizhao^[4,5,6];Wang, Pengbo^[8];Tong, Xia^[3];Liu, Lujie^[7];Wang, Lingwei^[4,5,6];Li, Baicun(李柏村)^[9]Chen, Zi^[10];Zhou, Linfu^[10];Zhang, Linshu^[11];Chen, Rongchang^[2,4,5,6,12];Sun, Changbin^[13];Xu, Wei^[13];Rao, Lang*^[7]Zhou, Haibo*^[4,5,6,14]Ding, BiSen*^[15]Chen, Shanze*^[4,5,6]
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2026 年 17 卷 1 期 ; MAR 20
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摘要：

Pulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and experimental fibrosis models induced by bleomycin or silica, we identify mechanosensitive Piezo1 upregulation in Endothelial cells as a hallmark of fibrotic progression. Endothelial-specific Piezo1 knockout significantly attenuates Bleomycin-induced fibrotic remodeling in male mice, establishing its pathogenic necessity. Mechanistically, PIEZO1 activation promotes pulmonary fibrosis development via CAPN2-mediated STAT3 phosphorylation, which may regulate the secretion of the pro-fibrotic molecule interleukin-33. These findings suggest that the endothelial PIEZO1-CAPN2-STAT3-IL33 axis is a potential therapeutic target for PF intervention.
推荐引用方式
GB/T 7714：

Zhang Lanlan,Gui Xuezhen,Hou Ruijie, et al. Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis [J].NATURE COMMUNICATIONS,2026,17(1).
APA：

Zhang Lanlan,Gui Xuezhen,Hou Ruijie,Jia Liping,&Chen Shanze.(2026).Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis .NATURE COMMUNICATIONS,17(1).
MLA：

Zhang Lanlan, et al. "Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis" .NATURE COMMUNICATIONS 17,1(2026).
入库时间：

2026/4/15 10:33:31
更新时间：

2026/4/15 10:33:31
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