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The association between disease status and health-related quality of life: evidence from a cross-sectional survey across mainland China 期刊论文

编号：

3BF68CD3590AFCCC55F4FD2DAA9802A3
作者：

Li, Xinyi(李欣燚)#^[1,2]Ma, Xuedi#^[3]Shi, Changcheng(史长城)^[2,4]Qin, Wangjun(覃旺军)^[1]Wu, Yibo*^[5,6]Liu, Lihong(刘丽宏)*^[1]
语种：

英文
期刊：

HEALTH AND QUALITY OF LIFE OUTCOMES ISSN：1477-7525 2026 年 24 卷 1 期 ; JAN 31
收录：
关键词：

Disease status Multimorbidity Health-related quality of life Cross-sectional survey
摘要：

Background This study aimed to assess the health-related quality of life (HRQoL) among Chinese adults with varying disease statuses. Methods A cross-sectional study was conducted between June 20 and August 31, 2023 across China. HRQoL was measured using the EQ-5D-5L utility index (UI) and EQ-Visual Analogue Scale (EQ-VAS). Kruskal-Wallis tests compared HRQoL across disease groups, chi-square tests compared problem prevalence within each EQ-5D-5L dimension across disease groups, and Tobit regression examined associations between disease status and HRQoL. Subgroup and interaction analyses assessed effect modification by age, gender, education, employment, and smoking status. Results A total of 42,447 participants were included (healthy: 33,408; single chronic disease: 5,084; multimorbidity: 3,955). HRQoL showed a clear gradient: median UI and EQ-VAS scores were 1 (0.95-1) and 80 (64-90) in healthy individuals, 0.95 (0.89-1) and 75 (61-83) in the single chronic disease group, and 0.89 (0.73-1) and 69 (54-81) in the multimorbidity group (all P < 0.001). Problem prevalence differed significantly among groups for all EQ-5D-5L dimensions. Age, education, smoking, and employment status modified associations between disease status and UI, yet single chronic disease and multimorbidity remained consistently linked to lower UI across all subgroups. Conclusions HRQoL declined from healthy individuals to those with single chronic disease and multimorbidity. The modifying effects of age, education, smoking, and employment status highlight priority subgroups for targeted interventions.
推荐引用方式
GB/T 7714：

Li Xinyi,Ma Xuedi,Shi Changcheng, et al. The association between disease status and health-related quality of life: evidence from a cross-sectional survey across mainland China [J].HEALTH AND QUALITY OF LIFE OUTCOMES,2026,24(1).
APA：

Li Xinyi,Ma Xuedi,Shi Changcheng,Qin Wangjun,&Liu Lihong.(2026).The association between disease status and health-related quality of life: evidence from a cross-sectional survey across mainland China .HEALTH AND QUALITY OF LIFE OUTCOMES,24(1).
MLA：

Li Xinyi, et al. "The association between disease status and health-related quality of life: evidence from a cross-sectional survey across mainland China" .HEALTH AND QUALITY OF LIFE OUTCOMES 24,1(2026).
入库时间：

2026/3/12 9:39:32
更新时间：

2026/3/12 9:39:32
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