Background: Peripheral Nerve Injury often cause severe functional impairments and long-term disability. There are various surgical methods to treat PNI, however they all have different shortcomings such as limited donor nerve choices and mismatch of nerve diameters. In addition, effective nerve function recovery also requires continuous nutritional support. Our study focused on the outcome of long-term resveratrol (RSV) supplementation in combination with small gap chitin conduits with variated diameters to promote nerve transfer repair. Methods: We constructed SD rat nerve transfer model with small gap conduit for tibial nerve repair. Then the rats were divided into saline, RSV, mecobalamin, and sham group, which receives different gavage treatments respectively. 16 weeks after surgery, the functional recovery of the tibial nerve was assessed in each group of rats. Results: Compared to the saline group, the RSV group and mecobalamin group showed enhanced performance in both motor function and nerve conduction, as well as improved histomorphology of both nerve and muscle fibers. Conclusion: Long-term RSV supplementation significantly improved functional recovery of tibial nerve after nerve transfer in small gap conduit with variated diameters.
[1]Peking Univ, Peoples Hosp, Dept Orthoped & Trauma, Beijing 100044, Peoples R China.
[2]Peking Univ, Key Lab Trauma & Neural Regenerat, Beijing 100044, Peoples R China.
[3]Natl Ctr Trauma Med, Beijing 100044, Peoples R China.
[4]China Japan Friendship Hosp, Dept Orthoped, Beijing, Peoples R China.
(8.0+极速模式)