Background: The epidemiology and severity of asthma vary by sex and age. The diagnosis, treatment, and management of asthma in female patients are quite challenging. However, there is hitherto no comprehensive and standardized guidance for female patients with asthma. Methods: Corresponding search strategies were determined based on clinical concerns regarding female asthma. Search terms included "sex hormones and lung development", "sex hormone changes and asthma", "hormones and asthma immune response", "women, asthma", "children, asthma", "puberty, asthma", "menstruation, asthma", "pregnancy, asthma", "lactation, asthma", "menopause, asthma", "obesity, asthma", and "women, refractory, severe asthma". Literature was retrieved from PubMed/Medline, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, Wanfang Data with the search date of July 30, 2022 as the last day. This consensus used the Grading of Recommendations Assessment, Development, and Evaluation to evaluate the strength of recommendation and quality of evidence. Results: We collected basic research results and clinical evidence -based medical data and reviewed the effects of sex hormones, classical genetics, and epigenetics on the clinical presentation and treatment response of female patients with asthma under different environmental effects. Based on that, we formulated this expert consensus on the management of female asthma throughout the life cycle. Conclusions: This expert consensus on the management of asthma in women throughout the life cycle provides diagnosis, treatment, and research reference for clinical and basic medical practitioners.
[1]Guangzhou Med Univ, Dept Allergy & Clin Immunol, Guangzhou Inst Resp Hlth,Affiliated Hosp 1, State Key Lab Resp Dis,Natl Clin Res Ctr Resp Dis, Guangzhou, Peoples R China.
[2]Guangzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Guangzhou, Peoples R China.
[3]Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Clin Med Coll 2,Shenzhen Peoples Hosp,Dept Pulm &, Shenzhen, Peoples R China.
[4]Sun Yat Sen Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guangzhou, Peoples R China.
[5]Zhejiang Univ, Dept Resp & Crit Care Med, Key Lab Resp Dis Zhejiang Prov, Affiliated Hosp 2,Sch Med, Hangzhou, Peoples R China.
[6]Fudan Univ, Zhongshan Hosp, Dept Allergy, Shanghai, Peoples R China.
[7]Chongqing Med Univ, Med Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Dept Res, Chongqing, Peoples R China.
[8]Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Endocrinol & Genet Metab Dis, Childrens Hosp,Minist Educ,Key Lab Child Dev & Dis, Chongqing, Peoples R China.
[9]China Japan Friendship Hosp, Natl Clin Res Ctr Resp Dis, Dept Pulm & Crit Care Med, Beijing, Peoples R China.
[10]Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Pediat, Guangzhou, Peoples R China.
[11]Shanghai Jiao Tong Univ, Shanghai Ruijin Hosp, Sch Med, Dept Pulm & Crit Care Med, Shanghai, Peoples R China.
[12]Gen Hosp Northern Theater Command, Dept Resp Med, Shenyang, Peoples R China.
[13]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Pulm & Crit Care Med, Shanghai, Peoples R China.
[14]Southern Med Univ, Nanfang Hosp, Dept Endocrinol & Metab, Guangzhou, Peoples R China.
[15]Capital Med Univ, Beijing Childrens Hosp, China Natl Clin Res Ctr Resp Dis, Natl Ctr Childrens Hlth,Resp Dept, Beijing, Peoples R China.
[16]Southern Med Univ, Nanfang Hosp, Dept Resp & Crit Care Med, Chron Airways Dis Lab, Guangzhou, Peoples R China.
[17]Guangzhou Med Univ, Affiliated Hosp 1, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis,Guangzhou Inst Resp Hlth,De, 28 Qiaozhong Middle Rd, Guangzhou 510120, Peoples R China.
[18]Southern Med Univ, Nanfang Hosp, Dept Resp & Crit Care Med, Chron Airways Dis Lab, 1838 Guangzhou Ave North, Guangzhou 510515, Peoples R China.
[19]Capital Med Univ, Beijing Childrens Hosp, China Natl Clin Res Ctr Resp Dis, Natl Ctr Childrens Hlth,Resp Dept, 56,Li Shi Rd, Beijing 100045, Peoples R China.
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