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Single-cell profiling unveils nephritis-related circulating immunological signatures in systemic lupus erythematosus patients 期刊论文

编号：

0032FF44A2B3930F2CFF13FE2C18EECB
作者：

Liu, Qun#^[1,2]Wu, Linjie#^[3,4]Hao, Sha^[3,4,5];Deng, Yiyao^[6];Liu, Xiaomin^[2,4];Shang, Shunlai(尚顺来)^[7]Zhou, Yena^[1,2];Zhang, Jie^[1,2];Li, Qinggang^[2];Li, Ping^[2];Zheng, Ying^[2];Bai, Xueyuan^[2];Wang, Xu^[2];Xie, Xiaowei^[3];Guo, Chaomin^[8];Yang, Liuyang^[8];Lin, Huayu^[9];Cai, Guangyan*^[1,2]Cheng, Tao*^[3,4,5]Chen, Xiangmei*^[1,2]
语种：

英文
期刊：

COMMUNICATIONS BIOLOGY ISSN：2399-3642 2026 年 9 卷 1 期 ; JAN 5
收录：
摘要：

Lupus nephritis (LN), the most severe complication of systemic lupus erythematosus (SLE), arises from systemic immune dysregulation and renal damage. While renal immune perturbations are well-studied, systemic signatures specific to LN pathogenesis remain unclear. Integrated single-cell RNA and immune repertoire analysis of 177,259 peripheral blood mononuclear cells (PBMCs) from healthy donors and SLE patients (including active LN and non-nephritis controls) revealed LN-specific circulating immune signatures, including kappa light-chain preference in naive B cells and distinct clonal expansion in CD8+ effector T cells. These clonally expanded CD8+ effector T cells exhibited transcriptional variations indicating increased migratory capacity and exhaustion, along with preferential usage of TRBV genes (TRBV27/TRBV15/TRBV7-9), which have enhanced binding potential to an EBV epitope GLCTLVAM. Based on these findings, we developed a dual-biomarker model demonstrating reliable LN diagnosis (AUC = 0.895). Cross-tissue analysis confirmed concordance between peripheral and intrarenal immune perturbations, supporting non-invasive blood-based monitoring. Enhanced MIF-(CD74 + CXCR4) axis activity linked to lymphocyte activation/migration, while CD74+ memory B cells upregulated MHC-I antigen presentation. Renal immunostaining revealed CD74+ B cells proximal to CD8+ T cell infiltrates, suggesting CD74-mediated crosstalk facilitates intrarenal T cell activation. This study provides an integrated LN immune atlas, identifies translatable biomarkers and highlights CD74 as a potential therapeutic target.
推荐引用方式
GB/T 7714：

Liu Qun,Wu Linjie,Hao Sha, et al. Single-cell profiling unveils nephritis-related circulating immunological signatures in systemic lupus erythematosus patients [J].COMMUNICATIONS BIOLOGY,2026,9(1).
APA：

Liu Qun,Wu Linjie,Hao Sha,Deng Yiyao,&Chen Xiangmei.(2026).Single-cell profiling unveils nephritis-related circulating immunological signatures in systemic lupus erythematosus patients .COMMUNICATIONS BIOLOGY,9(1).
MLA：

Liu Qun, et al. "Single-cell profiling unveils nephritis-related circulating immunological signatures in systemic lupus erythematosus patients" .COMMUNICATIONS BIOLOGY 9,1(2026).
入库时间：

2026/2/11 9:39:18
更新时间：

2026/2/11 9:39:18
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