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The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study

  • 作者:
    Li, GuangWei(李光伟)#*[2] Zhang, Ping(Zhang, Ping)*[1] Wang, JinPing(王金平)[3] Gregg, Edward W.[1] Yang, WenYing(杨文英)[2] Gong, QiuHong(巩秋红)[2] Li, Hui[3] Li, HongLiang(李宏亮)[2] Jiang, YaYun(姜亚云)[3] An, YaLi(安雅莉)[2] Shuai, Ying(帅瑛)[2] Zhang, Bo(张波)[2] Zhang, Jingling[3] Thompson, Theodore J.[1] Gerzoff, Robert B.[1] Roglic, Gojka[4] Hu, YingHua(胡英华)[3] Bennett, Peter H.[5]
  • 地址:

    [1]Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Diabet Translat, Atlanta, GA 30341 USA.

    [2]China Japan Friendship Hosp, Dept Endocrinol, Beijing 100029, Peoples R China.

    [3]Da Qing First Hosp, Dept Cardiol, Da Qing, Peoples R China.

    [4]WHO, Dept Chron Dis & Hlth Promot, CH-1211 Geneva, Switzerland.

    [5]NIDDKD, Phoenix Epidemiol & Clin Res Branch, NIH, Phoenix, AZ USA.

  • 语种:
    英文
  • 期刊:
    LANCET ISSN:0140-6736 2008 年 371 卷 9626 期 (1783 - 1789) ; MAY 24
  • 收录:
  • 摘要:

    Background Intensive lifestyle interventions can reduce the incidence of type 2 diabetes in people with impaired glucose tolerance, but how long these benefits extend beyond the period of active intervention, and whether such interventions reduce the risk of cardiovascular disease (CVD) and mortality, is unclear. We aimed to assess whether intensive lifestyle interventions have a long-term effect on the risk of diabetes, diabetes-related macrovascular and microvascular complications, and mortality.
    Methods In 1986, 577 adults with impaired glucose tolerance from 33 clinics in China were randomly assigned to either the control group or to one of three lifestyle intervention groups (diet, exercise, or diet plus exercise). Active intervention took place over 6 years until 1992. In 2006, study participants were followed-up to assess the long-term effect of the interventions. The primary outcomes were diabetes incidence, CVD incidence and mortality, and all-cause mortality.
    Findings Compared with control participants, those in the combined lifestyle intervention groups had a 51% lower incidence of diabetes (hazard rate ratio [HRR] 0 . 49; 95% CI 0 . 33-0-73) during the active intervention period and a 43% lower incidence (0 . 57; 0 . 41-0 . 81) over the 20 year period, controlled for age and clustering by clinic. The average annual incidence of diabetes was 7% for intervention participants versus 11% in control participants, with 20-year cumulative incidence of 80% in the intervention groups and 93% in the control group. Participants in the intervention group spent an average of 3.6 fewer years with diabetes than those in the control group. There was no significant difference between the intervention and control groups in the rate of first CVD events (HRR 0 . 98; 95% CI 0 . 71-1.37), CVD mortality (0 . 83; 0.48-1.40), and all-cause mortality (0 - 96; 0 . 65-1.41), but our study had limited statistical power to detect differences for these outcomes.
    Interpretation Group-based lifestyle interventions over 6 years can prevent or delay diabetes for up to 14 years after the active intervention. However, whether lifestyle intervention also leads to reduced CVD and mortality remains unclear.
    Funding Centers for Disease Control and Prevention, WHO, the China-Japan Friendship Hospital, and Da Qing First Hospital.

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  • 基金信息:
    PHS HHS [U58/CCU424123-01-02]
  • 推荐引用方式
    GB/T 7714:
    Li Guangwei,Zhang Ping,Wang Jinping, et al. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study [J].LANCET,2008,371(9626):1783-1789.
  • APA:
    Li Guangwei,Zhang Ping,Wang Jinping,Gregg Edward W.,&Bennett Peter H..(2008).The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study .LANCET,371(9626):1783-1789.
  • MLA:
    Li Guangwei, et al. "The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study" .LANCET 371,9626(2008):1783-1789.
  • 条目包含文件:
    文件类型:.pdf,文件大小:167.69 K
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