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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

  • 编号:
    b3a2fd07-bea4-4029-9a09-f783984c6692
  • 作者:
    Huang, Chaolin(huangchaolin)#[1] Wang, YeMing(王业明)#[2,5,6] Li, Xingwang(lixingwang)#[7] Ren, Lili(renlili)#[8] Zhao, Jianping(zhaojianping)#[10] Hu, Yi(huyi)#[11] Zhang, Li[1] Fan, GuoHui(范国辉)[2,3,5] Xu, Jiuyang[12] Gu, XiaoYing(谷晓颖)[2,3,5] Cheng, Zhenshun[13] Yu, Ting[1] Xia, Jiaan[1] Wei, Yuan[1] Wu, Wenjuan[1] Xie, Xuelei[1] Yin, Wen[11] Li, Hui(李辉)[2,5,6] Liu, Min(刘敏)[4] Xiao, Yan[8] Gao, Hong[9] Guo, Li[8] Xie, Jungang[10] Wang, Guangfa[14] Jiang, Rongmeng[7] Gao, Zhancheng[15] Jin, Qi[8] Wang, Jianwei(wangjianwei)*[8] Cao, Bin(曹彬)*[2,5,6,16]
  • 语种:
    英文
  • 期刊:
    LANCET ISSN:0140-6736 2020 年 395 卷 10223 期 (497 - 506) ; FEB 15
  • 收录:
  • 摘要:

    Background A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients.
    Methods All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not.
    Findings By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49.0 years (IQR 41.0-58.0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8.0 days [IQR 5.0-13.0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNF alpha.
    Interpretation The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Copyright (C) 2020 Elsevier Ltd. All rights reserved.

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  • 基金信息:
    Ministry of Science and Technology [2020YFC0841300]; Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences [CIFMS 2018-I2M-1-003]; National Science Grant for Distinguished Young Scholars [81425001/H0104]; National Key Research and Development Program of China [2018YFC1200102]; Beijing Science and Technology Project [Z19110700660000]; CAMS Innovation Fund for Medical Sciences [2016-I2M-1-014]; National Mega-projects for Infectious Diseases in China [2017ZX10103004, 2018ZX10305409]
  • 推荐引用方式
    GB/T 7714:
    Huang Chaolin,Wang Yeming,Li Xingwang, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].LANCET,2020,395(10223):497-506.
  • APA:
    Huang Chaolin,Wang Yeming,Li Xingwang,Ren Lili,&Cao Bin.(2020).Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China .LANCET,395(10223):497-506.
  • MLA:
    Huang Chaolin, et al. "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China" .LANCET 395,10223(2020):497-506.
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