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Comparison of influenza- and COVID-19-associated pulmonary aspergillosis in China 期刊论文

编号：

8439626FBDCFFA5ECDC2B2334A4619AF
作者：

Zhao, Jiankang(赵建康)#^[1]Zhuo, Xianxia(卓献霞)#^[1,2]Pu, Danni(蒲丹妮)^[1,3]Fan, Guohui(范国辉)^[1]Lu, Binghuai(鲁炳怀)*^[1,3]Cao, Bin(曹彬)*^[1,2,3,4]
语种：

英文
期刊：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES ISSN：0934-9723 2024 年 43 卷 4 期 (683 - 692) ; APR
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关键词：

COVID-19 Influenza Invasive pulmonary aspergillosis CAPA IAPA
摘要：

PurposeWe conducted a monocentric retrospective study using the latest definitions to compare the demographic, clinical, and biological characteristics of influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA).MethodsThe study retrospectively enrolled 180 patients, including 70 influenza/IPA patients (with positive influenza A/B and Aspergillus) and 110 COVID-19/IPA patients (with positive SARS-CoV-2 and Aspergillus). Among them, 42 (60%) and 30 (27.3%) patients fulfilled the definitions of IAPA and CAPA, respectively.ResultsThe CAPA patients had significantly higher in-hospital mortality (13/31, 41.9%) than IAPA patients (8/42, 19%) with a P-value of 0.033. Kaplan-Meier survival curve also showed significantly higher 30-day mortality for CAPA patients (P = 0.025). Additionally, the CAPA patients were older, though insignificantly, than IAPA patients (70 (60-80) vs. 62 (52-72), P = 0.075). A lower percentage of chronic pulmonary disease (12.9 vs. 40.5%, P = 0.01) but higher corticosteroids use 7 days before and after ICU admission (22.6% vs. 0%, P = 0.002) were found in CAPA patients. Notably, there were no significant differences in the percentage of ICU admission or ICU mortality between the two groups. In addition, the time from observation to Aspergillus diagnosis was significantly longer in CAPA patients than in IAPA patients (7 (2-13) vs. 0 (0-4.5), P = 0.048).ConclusionPatients infected with SARS-CoV-2 and Aspergillus during the concentrated outbreak of COVID-19 in China had generally higher in-hospital mortality but a lower percentage of chronic pulmonary disease than those infected with influenza and Aspergillus. For influenza-infected patients who require hospitalization, close attention should be paid to the risk of invasive aspergillosis upfront.
推荐引用方式
GB/T 7714：

Zhao Jiankang,Zhuo Xianxia,Pu Danni, et al. Comparison of influenza- and COVID-19-associated pulmonary aspergillosis in China [J].EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,2024,43(4):683-692.
APA：

Zhao Jiankang,Zhuo Xianxia,Pu Danni,Fan Guohui,&Cao Bin.(2024).Comparison of influenza- and COVID-19-associated pulmonary aspergillosis in China .EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,43(4):683-692.
MLA：

Zhao Jiankang, et al. "Comparison of influenza- and COVID-19-associated pulmonary aspergillosis in China" .EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 43,4(2024):683-692.
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