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Interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of 4330 Chinese patients with gastrointestinal tract cancer

  • 作者:
    Hui, Dan(huidan)#[1,2] Zhang, XinRan(张欣然)#[3] Lin, Xiandong[2,4] Zhang, Hejun[1,2] Xia, Yan[1,2] Lin, Jinxiu[5] Zheng, Xiongwei[1,2] Peng, Feng(pengfeng)*[5] Niu, WenQuan(牛文全)*[3]
  • 地址:

    [1]Fujian Canc Hosp, Dept Pathol, Fuzhou, Fujian, Peoples R China.

    [2]Fujian Med Univ, Canc Hosp, Fuzhou, Fujian, Peoples R China.

    [3]China Japan Friendship Hosp, Inst Clin Med Sci, Beijing, Peoples R China.

    [4]Fujian Canc Hosp, Dept Radiobiol, Fuzhou, Fujian, Peoples R China.

    [5]Fujian Med Univ, Dept Cardiol, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China.

  • 语种:
    英文
  • 期刊:
    JOURNAL OF CANCER ISSN:1837-9664 2020 年 11 卷 4 期 (867 - 873)
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  • 摘要:

    Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively.
    Methods and Results: 4330 patients were consecutively recruited between January 2000 and December 2010, with annual follow-up ending in December 2015. The median follow-up time was 48.6 months. Two optimal cutoff points for fasting blood glucose (6.11 and 11.69 mmol/L) were identified. Patients with fasting blood glucose <6.11 mmol/L and negative tumor embolus had the best survival, and the worst survival was seen in patients with fasting blood glucose >11.69 mmol/L and positive tumor embolus. The risk was highest for patients with fasting blood glucose >11.69 mmol/L and positive tumor embolus (adjusted HR: 11.91, 95% CI: 9.13 to 15.52). Using the Sobel-Goodman mediation test, the proportion of total effect conferred by tumor embolus that was mediated by fasting blood glucose was estimated to be 45.3%.
    Conclusions: Our findings indicate a synergistic interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of gastrointestinal tract cancer.

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  • 基金信息:
    Joint Funds for the Innovation of Science and Technology of Fujian Province [2018Y9113]; Natural Science Foundation of ChinaNational Natural Science Foundation of China [81970370, 81970042]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [3332018170]; Fujian Provincial Health Technology Project [2019-CX-29]
  • 推荐引用方式
    GB/T 7714:
    Hui Dan,Zhang Xinran,Lin Xiandong, et al. Interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of 4330 Chinese patients with gastrointestinal tract cancer [J].JOURNAL OF CANCER,2020,11(4):867-873.
  • APA:
    Hui Dan,Zhang Xinran,Lin Xiandong,Zhang Hejun,&Niu Wenquan.(2020).Interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of 4330 Chinese patients with gastrointestinal tract cancer .JOURNAL OF CANCER,11(4):867-873.
  • MLA:
    Hui Dan, et al. "Interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of 4330 Chinese patients with gastrointestinal tract cancer" .JOURNAL OF CANCER 11,4(2020):867-873.
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